Psy Press is pleased to present the 3rd edition of Enteroimmunology. This highly acclaimed volume has been extensively updated and expanded with an additional 100 pages of new subject matter. Enteroimmunology is the emerging field of medicine that studies the enteric immune system and microbial biome of the gut and their interaction with diet, digestion, the enteric and central nervous systems and endocrine functions. It explores and elucidates how these systems affect each other, and how they impact health and disease. The gastrointestinal mucosa is predominantly lined with enterocytes that form a continuous barrier from the beginning to the end of the digestive path. These cells absorb nutrients, while excluding the trillions of bacteria and other microbes that inhabit the gut. Just below the enterocytes, the mucosa contains over half of the body’s immune cells. These cells effect immune activity that protect the body from infection, however, they can also promote chronic inflammatory disease; not only of the intestines, but in any organ system. This book details the physiologic functions of the digestive and immune cells; their reactions to proteins, antigens and nutrients in the diet; the role of bacterial toxins and immune mediators; and the hormones that mediate appetite, GI motility and digestion. It explores the mechanisms occurring in immune dysfunction; when the protective immune response instead promotes chronic inflammation, responsible for depression, obesity, diabetes, acne, Alzheimer’s disease, cancer, migraines, schizophrenia, or other chronic inflammatory diseases. Enteroimmunology is a guide to the prevention and the reversal of chronic disease by first understanding, and then using diet and nutrition to reverse the underlying pathology of these diseases. Enteroimmunology explains the emerging understanding of the ecology of the gut and its relationship with diet, food and nutrition. It includes citations from over 2000 citations recent scientific journal articles. Dr. Lewis elucidates the physiology and pathophysiology of the intestinal and immune cells with clarity and humor that makes reading this book a pleasure. Enteroimmune disease is not limited to the bowel; diseases such as irritable bowel syndrome and inflammatory bowel diseases, but also include both systemic and neurological diseases. Neurological diseases discussed include autism, migraine, depression, multiple sclerosis, bipolar and rage disorders. Understanding the immune pathology underlying diseases local to immune reactions in the gut, it becomes clear how the same immune mechanisms can impact both the enteric and central nervous systems. It describes how IgG antergies to food, which are analogous to IgE allergies, cause a wide array of disease symptoms. This book explains leaky gut syndrome, small bowel overgrowth, dysbiosis, metabolic syndrome and how to achieve long-term effective resolution of these conditions through diet. The book gives examples of a variety of conditions and the pathological processes which underlie the causal mechanism of the diseases, and then provides a guide to the tertiary treatment for the condition. There are chapters on obesity and metabolic syndrome, fibromyalgia, autoimmune diseases, interstitial cystitis, sexual dysfunction, acne and other diseases. A chapter is dedicated to traumatic brain injury and its prevention. Another chapter is focuses on cancer prevention that explains the dietary factors responsible for the majority of human cancers, and which gives practical evidenced based advice for cancer prevention. There is a chapter explaining how the mitochondria and aging, detailing of how individuals can maintain vibrant, healthy, mitochondria. There are chapters on the role of sleep disorders in enteroimmune disease, explaining the role osteoimmunity in osteoporosis, disease, and on prevention of hearing loss.

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